Gambling of any kind is forbidden by Sharia law. The enforcement in this nation is rather lax compared to other countries, and gamers can still gamble online. Players may incur penalties if they are found out. However, the likelihood of this happening is extremely low.
Since the country's 2019 gambling ban, casinos are not permitted in Guinea-Bissau. There are no casinos, and even the establishments connected to hotels had to close. Slot rooms are also forbidden. Illegally run slot parlors were the main driver behind the gambling ban.
Operators probably won't set up shop in Guinea-Bissau anytime soon because Islam is the country's main religion. Players should have more reason to look for foreign casinos that welcome them.